First, preheat your oven to 425°F (220°C) and line a large baking sheet with parchment paper. This prevents the cauliflower from sticking and makes cleanup much easier. In a large bowl, whisk together the all-purpose flour, water, garlic powder, smoked paprika, salt, and pepper until you have a smooth, consistent batter.
Place the panko breadcrumbs in a separate shallow dish. Dip each cauliflower floret into the batter, ensuring it's fully coated, and let any excess drip off. Then, roll the battered floret in the panko breadcrumbs, pressing gently to make sure the crumbs adhere well. This two-step process is crucial for achieving that ultra-crispy exterior.
Arrange the coated cauliflower florets in a single layer on your prepared baking sheet. Be sure not to overcrowd the pan, as this can cause them to steam instead of crisp up. Bake for 20-25 minutes, or until they are golden brown and feel crispy to the touch. You can flip them halfway through for even browning.
While the cauliflower is baking, you can prepare the sauce. In a small saucepan, combine the honey, hot sauce, soy sauce, rice vinegar, and sesame oil. Warm the mixture over medium heat, stirring until all the ingredients are well combined and the sauce is smooth and slightly thickened. Don't let it boil, just heat it through.
Once the cauliflower is perfectly crispy, remove it from the oven. Place the hot cauliflower bites in a large bowl and pour the warm sauce over them. Gently toss everything together until each piece is evenly coated in the glaze. Garnish with optional sesame seeds and chopped green onions, and serve immediately for the best texture.