Start by softening your cream cheese and shredding the cheddar cheese. Open your Rotel tomatoes and drain slightly if needed. Pre-measure spices for easy mixing.
In a large mixing bowl, combine ground beef sausage, cream cheese, cheddar, Rotel, breadcrumbs, garlic powder, onion powder, salt, and pepper. Mix until fully combined.
Use your hands or a small cookie scoop to form bite-sized balls. Aim for uniform size so they cook evenly. Place them on a parchment-lined baking sheet.
Preheat your oven to 375°F (190°C). Bake the sausage balls for 20-25 minutes or until golden brown and fully cooked inside.
Allow the sausage balls to cool slightly before serving. You can also chill them for later use. They hold together well and stay flavorful.